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Molecular dynamics of biological macromolecules: A brief history and perspective
Contents:
  1. Weitere vorgeschlagene Titel
  2. All Nobel Prizes in Chemistry
  3. 68th Symposium on Macromolecules
  4. Weitere vorgeschlagene Titel

  1. The Contextual Challenges of Occupational Sex Segregation: Deciphering Cross-National Differences in Europe.
  2. PhD Position "Dynamics and charge transport in individualized macromolecules".
  3. Topics - 68th SPSJ Symposium on Macromolecules;

The ensemble nature of proteins has far-reaching implications for understanding basic natural protein functions such as ligand binding, enzyme catalysis, and allostery. By extension, an understanding of protein dynamics should lead to improvements in protein engineering and rational drug design.

This includes enzymes such as dihydrofolate reductase DHFR , which is essential in all organisms for nucleotide biosynthesis. It is also the target for drugs used to treat human cancers and antibiotics and is therefore an excellent system for studying protein-drug interactions.

Weitere vorgeschlagene Titel

These are found throughout nature in a variety of contexts and are widespread as signal transduction modules in higher eukaryotes. PDZ domains specialize in binding C-terminal sequences of signaling enzymes, transmembrane receptors, proteases, etc.

Macromolecules - Classes and Functions

They are also recognized as models for intramolecular communication. Other ongoing projects in the lab are directed at the role of protein dynamics in allostery and their distinguishing features from non-allosteric proteins. How does Lee characterize protein dynamics? Thee preferred method is heteronuclear NMR spectroscopy, which is uniquely suited to study both structure and dynamics in proteins and other biological macromolecules.

All Nobel Prizes in Chemistry

A major advantage of NMR is that spectroscopic probes are distributed uniformly throughout the biomolecule , such as NH or CH atom pairs, providing large amounts of molecular information. To gain information on protein dynamics, NMR spin relaxation is highly sensitive to molecular motion over a range of timescales. The Physics and Psychophysics of Music.

Juan G. Biological Adhesives. Andrew M. Me and the Biospheres. John Allen. Forgotten Women: The Scientists. Zing Tsjeng. Multiple Stable States in Natural Ecosystems.

Peter Petraitis. Cereals: Novel Uses and Processes. Grant M. Vexing Nature? Gary L. Pollen Biotechnology.

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68th Symposium on Macromolecules

Origins of Biogeography. Malte Christian Ebach. Biomaterials Science. Buddy D. Social Networks and Natural Resource Management. Krishnarao Appasani. Protein Hydrolysates in Biotechnology. Vijai K. Successful Agricultural Innovation in Emerging Economies. David J. Why Does the World Stay Green? TCR White. Chris A. Intercellular Signalling in the Mammary Gland. Bioengineering and Molecular Biology of Plant Pathways. Henry Nguyen.

Biofluid Mechanics. David Rubenstein.

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Dormancy and Resistance in Harsh Environments. Joan Cerda. Computational Methods in Molecular Biology. Modelling Protocells. Roberto Serra. Environmental and Agricultural Modelling:. Floor M. Microbial Megaplasmids. Edward Schwartz. Microtechnology for Cell Manipulation and Sorting. Wonhee Lee. Current Ornithology.

Charles F. From Plant Genomics to Plant Biotechnology. Palmiro Poltronieri. Cellular and Molecular Biology of Mammary Cancer. The Biology of Subcellular Nitric Oxide. Derek LeRoith. Advances in Citrus Nutrition. Anoop Kumar Srivastava. Karl-Hermann Neumann.